DR6 antibody [Luke-1]

GeneTex

DR6 antibody [Luke-1]

9

Flow Cytometry

Research Use Only

Monoclonal

Luke-1

Unconjugated

TNFRSF21

TNF receptor superfamily member 21

BM-018; CD358; death receptor 6; DR6; TNFR-related death receptor 6; tumor necrosis factor receptor superfamily member 21

Rat

IgG2a

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.

Human

2°C to 8°C

12352203