DRAM antibody

GeneTex

DRAM antibody

9

This antibody is specific for DRAM N-Terminus

WB: 0.5 - 2 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

DRAM1

DNA damage regulated autophagy modulator 1

damage-regulated autophagy modulator; DNA damage-regulated autophagy modulator protein 1; DRAM

Rabbit

IgG

DNA damage-regulated autophagy modulator protein 1

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203