DTL antibody

Biorbyt

DTL antibody

16

Western Blot

WB:1:500-1:1000 WB

Research Use Only

Polyclonal

Unconjugated

DTL

denticleless E3 ubiquitin protein ligase homolog

CDT2; DCAF2; DDB1- and CUL4-associated factor 2; denticleless protein homolog; L2DTL; lethal(2) denticleless protein homolog; RAMP; RA-regulated nuclear matrix-associated protein; retinoic acid-regulated nuclear matrix-associated protein

Rabbit

Denticleless protein homolog

Rabbit polyclonal to DTL.Denticleless protein homolog (DTL) belongs to the WD repeat cdt2 family. It is a substrate-specificadapter for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cyclecontrol, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also namedCRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 andCDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure propercell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or followingUV irradiation is essential to control replication licensing. In undamaged proliferating cells, theDCX(DTL) complex promotes the Lys-164 monoubiquitination of PCNA to regulate PCNA-dependenttranslesion DNA synthesis.

Human

-20°C

12352203