Western blot analysis of extracts of mouse brain cell lines, using DTNBP1 antibody.
Western blot analysis of extracts of mouse brain cell lines, using DTNBP1 antibody.
DTNBP1 Antibody
CSB-PA007218KA01HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetDTNBP1
Overview
- SupplierCusabio
- Product NameDTNBP1 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID84062
- Target nameDTNBP1
- Target descriptiondystrobrevin binding protein 1
- Target synonymsbiogenesis of lysosomal organelles complex-1, subunit 8; biogenesis of lysosome-related organelles complex 1 subunit 8; BLOC-1 subunit 8; BLOC1S8; DBND; dysbindin; dysbindin-1; Hermansky-Pudlak syndrome 7 protein; HPS7; My031; SDY
- HostRabbit
- IsotypeIgG
- Protein IDQ96EV8
- Protein NameDysbindin
- Scientific DescriptionDysbindin, or dystrobrevin-binding protein 1, is a coiled-coil-containing protein expressed in muscle and brain that was identified as a binding partner of dystrobrevin. Dysbindin upregulates expression of the pre-synaptic proteins SNAP25 and synapsin I, thereby increasing glutamate release and promoting neuronal viability through Akt signaling. In particular, Akt phosphorylation is suppressed with downregulation of dysbindin and increased with upregulation of dysbindin. A nonsense mutation of dysbindin causes Hermansky-Pudlak disease, an autosomal recessive disorder characterized by lysosomal storage defects and prolonged bleeding. Genetic variation in the gene encoding dysbindin is strongly associated with schizophrenia and protein levels are reduced in the prefrontal cortex, midbrain and hippocampus of brains from patients with schizophrenia.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203