Immunofluorescent analysis of Hela cells using CSB-PA773055LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of Hela cells using CSB-PA773055LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
DTX1 Antibody
CSB-PA773055LA01HU
ApplicationsImmunoFluorescence, ELISA
Product group Antibodies
ReactivityHuman
TargetDTX1
Overview
- SupplierCusabio
- Product NameDTX1 Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1840
- Target nameDTX1
- Target descriptiondeltex E3 ubiquitin ligase 1
- Target synonymsdeltex 1, E3 ubiquitin ligase; deltex homolog 1; E3 ubiquitin-protein ligase DTX1; hDx-1; protein deltex-1; RING-type E3 ubiquitin transferase DTX1; RNF140
- HostRabbit
- IsotypeIgG
- Protein IDQ86Y01
- Protein NameE3 ubiquitin-protein ligase DTX1
- Scientific DescriptionFunctions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203