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ProductsBack/Dynasore [1202867-00-2]
Chemical Structure
Chemical Structure
Chemical Structure

Dynasore [1202867-00-2]

Research Use Only
AG-CR1-0045
AdipoGen Life Sciences
CAS Number1202867-00-2
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight322.3 . 9.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Dynasore [1202867-00-2, 304448-55-3]
  • Delivery Days Customer
    10
  • ADR Class
    9
  • CAS Number
    1202867-00-2
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Excepted quantity,Warning
  • Molecular Formula
    C18H14N2O4 . 0.5H2O
  • Molecular Weight
    322.3 . 9.0
  • Scientific Description
    Chemical. CAS: 304448-55-3 (free base) 1202867-00-2 (x H2O). Formula: C18H14N2O4 . 0.5H2O. MW: 322.3 . 9.0. Dynamin-1, -2 (DNM1, DNM2) and Dynamin-related protein 1 (DRP1) inhibitor. Endocytosis inhibitor. Viral infection inhibitor. Destabilizes actin filaments. Inhibits entry of Trypanosoma into macrophages. Inhibitor of mitophagy. Inhibitor of hepatocyte lipophagy - Dynamin-1, -2 (DNM1, DNM2) and Dynamin-related protein 1 (DRP1) inhibitor [1]. Endocytosis inhibitor [1, 2]. Viral infection inhibitor [3]. Destabilizes actin filaments [4]. Inhibits entry of Trypanosoma into macrophages [5]. Inhibitor of mitophagy. Inhibitor of hepatocyte lipophagy
  • SMILES
    OC1=CC2=C(C=CC=C2)C=C1C(=O)N\N=C\C1=CC(O)=C(O)C=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UN Number
    UN 3077
  • UNSPSC
    12352200

References

  • Dynasore, a cell-permeable inhibitor of dynamin.: E. Macia, et al. ; Dev. Cell. 10, 839 (2006)
  • Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis: T. Kirchhausen, et al.; Meth. Enzymol. 438, 77 (2008)
  • HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore: C.Y. Abban, et al.; Am. J. Ther. 15, 304 (2008)
  • Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments: H. Yamada, et al.; BBRC 390, 1142 (2009)
  • Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages: E.S. Barrias, et al.; PLoS One 5, e7764 (2010)
  • Mitochondrial dynamics and mitophagy in the 6-hydroxydopamine preclinical model of Parkinson's disease: M.F. Galindo, et al.; Parkinsons Dis. 131058 (2012)
  • A well-oiled machine: DNM2/dynamin 2 helps keep hepatocyte lipophagy running smoothly: RJ. Schulze & MA. McNiven; Autophagy 10, 388 (2013)
  • Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT: R. Padmanabhan & L.A. Taneyhill; J. Cell Sci. 128, 1773 (2015)