DYR684

MedChem Express

DYR684

9

Research Use Only

C58H58FN15O5

1064.18

DYR684 is a PROTAC of the protein kinases DYRK1A. DYR684 promotes fast, efficient, potent, and selective degradation of DYRK1A in cell-based assays. (Pink: ligand for target protein (HY-168195); Black: linker (HY-168200); Blue: ligand for E3 ligase (HY-168198))[1].

O=C(C(N(C(C1=C2C=CC=C1NCC3=CN(C4CCN(C(C5CCN(C6=NC=C(C#CCN7CCN(C8=CC=C(N9C(C)=NC%10=CC=C(C%11=CC(N)=NC=C%11)N=C%109)C=C8F)CC7)C=C6)CC5)=O)CC4)N=C3)=O)C2=O)CC%12)NC%12=O

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