E2F4 antibody, PAb

Biorbyt

E2F4 antibody, PAb

10

Western Blot

Western blot - 0.1-0.5 μg/ml - Human, Rat - - - WB

Research Use Only

Polyclonal

500 ug/ml

Rabbit

IgG

Rabbit polyclonal to E2F4. Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. The protein encoded by this gene is a member of the E2F family of transcription factors. This gene is mapped to 16q22.1. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

Human, Rat

2°C to 8°C,-20°C

12352203