Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using E2F4 Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using E2F4 Polyclonal Antibody at dilution 1:40
E2F4 Polyclonal Antibody
E-AB-12375
Product group Antibodies
Overview
- SupplierElabscience
- Product NameE2F4 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.5mg/ml
- Scientific DescriptionThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two.
- UNSPSC12352203