E3 Ligase Ligand-linker Conjugate 81

MedChem Express

E3 Ligase Ligand-linker Conjugate 81

14

Research Use Only

C30H39N5O6

565.66

(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

O=C1NC(CCC1N2C(C3=C(C=CC(N4[C@H]5CN([C@H](C5)C4)C[C@H]6CC[C@@H](CC6)NC(OC(C)(C)C)=O)=C3)C2=O)=O)=O

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