E3 Ligase Ligand-linker Conjugate 83

MedChem Express

E3 Ligase Ligand-linker Conjugate 83

14

Research Use Only

C31H43N5O6

581.70

(1r,4r)-Thalidomide-piperidine-N(Me)-CH-cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (1r,4r)-Thalidomide-piperidine-N(Me)-CH-cyclohexane-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

O=C1NC(CCC1N2C(C3=C(C=CC(N4CCC(CC4)N(C)C[C@H]5CC[C@@H](CC5)NC(OC(C)(C)C)=O)=C3)C2=O)=O)=O

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