E3 Ligase Ligand-linker Conjugate 85

MedChem Express

E3 Ligase Ligand-linker Conjugate 85

14

Research Use Only

C33H47N7O6S

669.83

(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH can be used as a key intermediate for the synthesis of complete PROTAC molecules.

O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(CN2CC(C2)N3CCN(CC3)CC(O)=O)=O)=O)NCC(C=C4)=CC=C4C(SC=N5)=C5C

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