EB-47 (dihydrochloride)

MedChem Express

EB-47 (dihydrochloride) [1190332-25-2]

10

1190332-25-2

Research Use Only

99.68

C24H29Cl2N9O6

610.45

EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC 50 value of 45 nM, shows modest potency against ARTD5 with an IC 50 value of 410 nM. EB-47 mimics the substrate NAD + ?and extends from the nicotinamide to the adenosine subsite [1] .

O=C1NCC2=C(C=CC=C21)NC(CN3CCN(CC3)C([C@H]4O[C@H]([C@@H]([C@@H]4O)O)N5C6=C(N=C5)C(N)=NC=N6)=O)=O.[H]Cl.[H]Cl

2°C to 8°C

12352200