EGFR-IN-117 [3035639-05-2]

TargetMol Chemicals

EGFR-IN-117 [3035639-05-2]

9

Research Use Only

C25H30BrN7O2S

572.52

EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3-C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.

O=S(=O)(NC=1C=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)N4CCN(C)CCC4)C5CC5

-20°C

51202000