EGFR-IN-97

MedChem Express

EGFR-IN-97

14

Research Use Only

C37H36N8O2

624.73

EGFR-IN-97 (compound 6q) is a EGFR inhibitor. EGFR-IN-97 shows inhibitory activity against Ba/F3-EGFR L858R/T790M/C797S and Ba/F3-EGFR Del19/T790M/C797S cells, with IC 50 values of 0.42 microM and 0.41 microM, respectively. EGFR-IN-97 can promote apoptosis of NCI-H1975-EGFR L858R/T790M/C797S cells at the concentration of 0.8 microM [1] .

NC1=NC=CC(NC(C=C2)=CC=C2NC([C@@H](C3=CC=CC=C3)N4CC5=CC(C6=CC=C(N7CCN(CC7)C)C=C6)=CC=C5C4=O)=O)=N1

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