EGLN1 / PHD2 Antibody
ORB639874
ApplicationsImmunoHistoChemistry
Product group Antibodies
Overview
- SupplierBiorbyt
- Product NameEGLN1 / PHD2 Antibody
- Delivery Days Customer16
- ApplicationsImmunoHistoChemistry
- Applications SupplierWestern blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml IHC-P, WB
- CertificationResearch Use Only
- Clone ID366G/76/3
- IsotypeIgG
- Scientific Description366G/76/3 recognises human prolyl hydroxylase 2 (PHD2), a 46kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.
- UNSPSC12352203