EIF3A Polyclonal Antibody

Reddot Biotech

EIF3A Polyclonal Antibody

5

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

EIF3A

eukaryotic translation initiation factor 3 subunit A

centrosomin homolog; cytoplasmic protein p167; EIF3; eIF3 p167; eIF3 p180; eIF3 p185; EIF3, p180 subunit; eIF3-p170; EIF3S10; eIF-3-theta; eIF3-theta; eukaryotic translation initiation factor 3 subunit 10; eukaryotic translation initiation factor 3 subunit A; eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD); eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD); eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa; eukaryotic translation initiation factor 3, subunit 10, 170kD; P167; p180; p185; TIF32

Rabbit

IgG

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Human, Mouse

-20°C

12352203