Western blot analysis of extracts from HepG2 and 293 cells using 4E-BP1(Ab-36) Antibody.
Western blot analysis of extracts from HepG2 and 293 cells using 4E-BP1(Ab-36) Antibody.
EIF4EBP1 (Ab-36) Antibody
CSB-PA118316
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetEIF4EBP1
Overview
- SupplierCusabio
- Product NameEIF4EBP1 (Ab-36) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1978
- Target nameEIF4EBP1
- Target descriptioneukaryotic translation initiation factor 4E binding protein 1
- Target synonyms4EBP1; 4E-BP1; BP-1; eIF4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; phosphorylated heat- and acid-stable protein regulated by insulin 1
- HostRabbit
- IsotypeIgG
- Scientific Description4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Gingras AC, et al. Genes Dev Nov. 2005 Feb 15. Mothe-Satney I, et al.(2000) J Biol Chem:15(21): 2852-64. Gingras AC, et al. (1999) Genes Dev:13(11): 1422-37. Lal L, et al.(2005) Blood;105(4): 1669-7.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C
- UNSPSC12352203