ELA-21 (human) [2245073-05-4]

TargetMol Chemicals

ELA-21 (human) [2245073-05-4]

9

2245073-05-4

Research Use Only

C112H184N40O25S3

2587.12

High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates beta-arrestin recruitment in vitro.

C(N[C@H](C(=O)N1[C@H](C(O)=O)CCC1)CC2=CC=CC=C2)(=O)[C@H]3N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)NC([C@@H](NC(=O)[C@H]5N(C([C@@H](NC(=O)[C@H]6NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC([C@@H](NC([C@H](CC7=CN=CN7)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CCCNC(=N)N)=O)CCCCN)=O)=O)CC(N)=O)=O)CSSC6)CCSC)=O)CCC5)CC(C)C)=O)=O)CO)=O)CCCNC(=N)N)=O)C(C)C)=O)CCC3

-20°C

12352200