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AG-45A-0029Y | Sirtuin 1 (human) (IntraCellular) ELISA Kit | AdipoGen Life Sciences products available at Bio-Connect

Sirtuin 1 (human) (IntraCel... | AG-45A-0029Y | AdipoGen Life Sciences

Sirtuin 1 (human) (IntraCellular) ELISA Kit

ELISA Assay. Detects human sirtuin1. Does not cross-react with human sirtuin2, human sirtuin5, human sirtuin5 (intact form) or human sirtuin6. Colorimetric assay. Sample Types: Cell Lysate. Range: 0.032 to 2ng/ml. Sensitivity: 30pg/ml. Sirtuins (Silent information regulators; SIRTs) deacetylate and/or ADP-ribosylate lysine residues of target proteins in an NAD+-dependent manner. Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle and apoptosis. Sirtuins, in particular SIRT1, emerged as critical regulators of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimers disease are associated with sirtuins. SIRT1 has been suggested as potential biomarker for tumorigenesis. - Sirtuins (Silent information regulators; SIRTs) deacetylate and/or ADP-ribosylate lysine residues of target proteins in an NAD+-dependent manner. Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle and apoptosis. Sirtuins, in particular SIRT1, emerged as critical regulators of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimers disease are associated with sirtuins. SIRT1 has been suggested as potential biomarker for tumorigenesis.

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