ELOVL6-IN-5 [1135000-36-0]

TargetMol Chemicals

ELOVL6-IN-5 [1135000-36-0]

9

Research Use Only

C20H20F3N3O3S

439.45

ELOVL6-IN-5 (compound B) acts as an inhibitor targeting the elongase enzyme of the long-chain fatty acid family 6 (ELOVL6). This enzyme is pivotal in the elongation process of saturated and monounsaturated long-chain fatty acids, marking it as a strategic target for diabetes intervention. In a mouse model of diet-induced obesity (DIO), ELOVL6-IN-5 effectively reduces hepatic fatty acid levels. However, it fails to enhance insulin sensitivity.

O=C(NC1=CC=C(C=C1)C(F)(F)F)N2C3CCC2CC(C3)S(=O)(=O)C4=NC=CC=C4

-20°C

51202000