Elsubrutinib

Selleck Chemicals

Elsubrutinib [1643570-24-4]

9

Research Use Only

...

Elsubrutinib(ABBV-105) is a covalent, irreversible, potent, and highly selective inhibitor of Brutons Tyrosine Kinase (BTK), with an IC50 of 0.18 microM for BTK catalytic domain. It specifically inhibits BTK dependent cellular functions, including both BCR and FcgammaR mediated signaling. It also exhibits significant efficacy in pre-clinical mechanistic models of antibody production, as well as in models of rheumatoid arthritis and lupus.

51202000