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EM20-25

HY-101999
MedChem Express
CAS Number141266-44-6
DownloadMSDS
Product group Chemicals
Molecular Weight376.71
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Overview

  • Supplier
    MedChem Express
  • Product Name
    EM20-25 [141266-44-6]
  • Delivery Days Customer
    5
  • CAS Number
    141266-44-6
  • Certification
    Research Use Only
  • Molecular Formula
    C15H9ClN4O6
  • Molecular Weight
    376.71
  • Scientific Description
    EM20-25 is an inhibitor for Bcl-2 , which interferes with the interaction between BCL-2 and BAX, activates caspase-9 and thus induces the apoptosis . EM20-25 affects the mitochondrial function, causes the open of permeability transition pore (PTP). EM20-25 enhances the sensitivity of cells to Staurosporine (HY-15141), and enhances the killing effect of BCL-2-expressing leukemia cells to Chlorambucil (HY-13593) and Fludarabine (HY-B0069) [1] .
  • SMILES
    O=C1NC(C(C2C3=CC(Cl)=CC=C3OC(NC(N4)=O)=C2C4=O)C(N1)=O)=O
  • UNSPSC
    12352200