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EMI1(EMI1/1176), CF405S conjugate, 0.1mg/mL [26628-22-8]

EMI1(EMI1/1176), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC041176
Biotium
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetFBXO5
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Overview

  • Supplier
    Biotium
  • Product Name
    EMI1(EMI1/1176), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    EMI1/1176
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID26271
  • Target name
    FBXO5
  • Target description
    F-box protein 5
  • Target synonyms
    early mitotic inhibitor 1; EMI1; F-box only protein 5; F-box protein Fbx5; FBX5; Fbxo31
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDQ9UKT4
  • Protein Name
    F-box only protein 5
  • Scientific Description
    This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203