![EMI1(EMI1/1176), CF405S conjugate, 0.1mg/mL [26628-22-8] EMI1(EMI1/1176), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2016/12/BNUB1176-0-1.jpg)
EMI1(EMI1/1176), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC041176
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetFBXO5
Overview
- SupplierBiotium
- Product NameEMI1(EMI1/1176), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDEMI1/1176
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID26271
- Target nameFBXO5
- Target descriptionF-box protein 5
- Target synonymsearly mitotic inhibitor 1; EMI1; F-box only protein 5; F-box protein Fbx5; FBX5; Fbxo31
- HostMouse
- IsotypeIgG2a
- Protein IDQ9UKT4
- Protein NameF-box only protein 5
- Scientific DescriptionThis antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203