Empasiprubart [2579031-19-7]

TargetMol Chemicals

Empasiprubart

9

2579031-19-7

Antibody

Research Use Only

Empasiprubart

Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. It inhibits the formation of C3 proconvertase, obstructing classical and lectin pathway activation by binding to the Sushi-2 domain of C2 upstream of C3. The binding of Empasiprubart is pH- and calcium-dependent. The compound demonstrates efficacy in preventing complement-mediated cytotoxicity within in vitro models of autoimmune hemolytic anemia and antibody-mediated organ transplant rejection [1].

3 years

-20°C

12352203