EN171
HY-W1005067
Molecular Weight270.37
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameEN171
- Delivery Days Customer9
- CertificationResearch Use Only
- Molecular FormulaC17H22N2O
- Molecular Weight270.37
- Scientific DescriptionEN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERalpha, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol [1] .
- SMILESO=C(N1CCC2(CN(CC2)CC3=CC=CC=C3)C1)C=C
- UNSPSC12352200