Bio-Connect

EN171

HY-W1005067
MedChem Express
Molecular Weight270.37
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    EN171
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C17H22N2O
  • Molecular Weight
    270.37
  • Scientific Description
    EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERalpha, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol [1] .
  • SMILES
    O=C(N1CCC2(CN(CC2)CC3=CC=CC=C3)C1)C=C
  • UNSPSC
    12352200