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ProductsBack/ENaC gamma antibody

ENaC gamma antibody

Research Use Only
ORB152756
Biorbyt
ApplicationsWestern Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityAmphibian, Hamster, Human, Mouse, Rat
TargetScnn1g
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Overview

  • Supplier
    Biorbyt
  • Product Name
    ENaC gamma antibody
  • Delivery Days Customer
    16
  • Application Supplier Note
    1 microg/ml of SPC-405 was sufficient for detection of gamma-ENaC in 20 microg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
  • Applications
    Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
  • Applications Supplier
    WB (1:1000), IHC (1:100) ICC, IHC, WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    RPE
  • Gene ID24768
  • Target name
    Scnn1g
  • Target description
    sodium channel epithelial 1 subunit gamma
  • Target synonyms
    amiloride sensitive sodium channel gamma1 subunit; amiloride-sensitive sodium channel subunit gamma; ENaC; epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; gamma-ENaC; gamma-NaCH; nonvoltage-gated sodium channel 1 subunit gamma; SCNEG; sodium channel epithelial 1 gamma subunit; Sodium channel, nonvoltage-gated 1, gamma (epithelial); sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated, type I, gamma
  • Host
    Rabbit
  • Protein IDP37091
  • Protein Name
    Amiloride-sensitive sodium channel subunit gamma
  • Scientific Description
    Rabbit polyclonal to ENaC Gamma (RPE). The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport. Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption. ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta , and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate. The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure..
  • Reactivity
    Amphibian, Hamster, Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203