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Entacapone sodium salt

T11207
TargetMol Chemicals
CAS Number1047659-02-8
Product group Chemicals
Molecular Weight328.28
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Entacapone sodium salt
  • Delivery Days Customer
    72
  • CAS Number
    1047659-02-8
  • Category Supplier
    Chemical
  • Chemical Name
    Entacapone sodium salt
  • Molecular Formula
    C14H15N3NaO5
  • Molecular Weight
    328.28
  • Scientific Description
    Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 uM) is a potent inhibitor of alfa-syn and bèta-amyloid (Abèta) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.
  • Shelf life instruction
    3 years
  • SMILES
    [Na].CCN(CC)C(=O)C(=C\c1cc(O)c(O)c(c1)N(=O)=O)\C#N
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Di Giovanni, S., et al., Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem, 2010. 285(20): p. 14941-54.
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