Entacapone sodium salt [1047659-02-8]

TargetMol Chemicals

Entacapone sodium salt

72

1047659-02-8

Chemical

Research Use Only

Entacapone sodium salt

C14H15N3NaO5

328.28

Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 microM) is a potent inhibitor of alpha-syn and beta-amyloid (Abeta) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

3 years

[Na].CCN(CC)C(=O)C(=C\c1cc(O)c(O)c(c1)N(=O)=O)\C#N

-20°C

12352200