EOS (d18:1/32:1/18:2) [1318771-31-1]

TargetMol Chemicals

EOS (d18:1/32:1/18:2) [1318771-31-1]

999

1318771-31-1

Chemical

Research Use Only

EOS (d18:1/32:1/18:2)

C68H127NO5

1038.766

EOS is a ceramide found in the outer layer of the epidermis in mammals. It is comprised of an omega-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid . The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the omega-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte.

3 years

CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCC\C=C/CCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC

-20°C

12352200