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ProductsBack/EPHA2/EPHA5 (Ab-594) Antibody
Western blot analysis of extracts from JK cells (Lane 2), using EPHA2/5 (Ab-594) antiobdy. The lane on the left is treated with synthesized peptide.
Western blot analysis of extracts from JK cells (Lane 2), using EPHA2/5 (Ab-594) antiobdy. The lane on the left is treated with synthesized peptide.
Western blot analysis of extracts from JK cells (Lane 2), using EPHA2/5 (Ab-594) antiobdy. The lane on the left is treated with synthesized peptide.

EPHA2/EPHA5 (Ab-594) Antibody

Research Use Only
CSB-PA988333
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetEPHA2
Price on request
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    Cusabio
  • Product Name
    EPHA2/EPHA5 (Ab-594) Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID1969
  • Target name
    EPHA2
  • Target description
    EPH receptor A2
  • Target synonyms
    ARCC2; CTPA; CTPP1; CTRCT6; ECK; ephrin type-A receptor 2; epithelial cell receptor protein tyrosine kinase; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP29317
  • Protein Name
    Ephrin type-A receptor 2
  • Scientific Description
    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990). Gregory S.G., Nature 441:315-321(2006).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203