ERalpha degrader 10

MedChem Express

ERalpha degrader 10

9

Research Use Only

C29H25ClN2O2

468.97

ERalpha degrader 10 is a selective and orally active estrogen receptor alpha (ERalpha) degrader. ERalpha degrader 10 exhibits potent ERalpha binding affinity (IC50 of 24.0 nM) and degradation ability (EC50 of 5.3 nM). ERalpha degrader 10 degrades ERalpha through the proteasome-mediated pathway. ERalpha degrader 10 can be used for the study of breast cancer[1].

O=C(O)/C=C/C1=CC=C(/C(C2=CC=C(C3=CN(C)N=C3)C=C2)=C(C4=CC=CC=C4Cl)/CC)C=C1

12352200