ERAP1 Antibody

Cusabio

ERAP1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

ERAP1

endoplasmic reticulum aminopeptidase 1

adipocyte-derived leucine aminopeptidase; ALAP; A-LAP; aminopeptidase PILS; aminopeptidase regulator of TNFR1 shedding; APPILS; ARTS1; ARTS-1; CTD-2260A17.2; endoplasmic reticulum aminopeptidase 1; endoplasmic reticulum aminopeptidase associated with antigen processing; ERAAP; ERAAP1; PILSAP; PILS-AP; puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

Rabbit

IgG

Endoplasmic reticulum aminopeptidase 1

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Hattori A., J. Biochem. 130:235-241(2001). Nakajima D., DNA Res. 9:99-106(2002). Clark H.F., Genome Res. 13:2265-2270(2003).

Human, Mouse, Rat

-20°C or -80°C

12352203