ERCC1 / RAD10 (Tumor Progression Marker)(ERCC1/2683), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

ERCC1 / RAD10 (Tumor Progression Marker)(ERCC1/2683), CF594 conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

ERCC1/2683

0.1 mg/ml

Other Conjugate

ERCC1

ERCC excision repair 1, endonuclease non-catalytic subunit

COFS4; DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); RAD10; UV20

Mouse

IgG1

DNA excision repair protein ERCC-1

Recognizes a protein of 110 kDa, identified as Excision Repair Cross Complementing 1 (ERCC1). It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203