Bio-Connect

ERCC6L Polyclonal Antibody

RD75800A
Reddot Biotech
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetERCC6L
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    ERCC6L Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID54821
  • Target name
    ERCC6L
  • Target description
    ERCC excision repair 6 like, spindle assembly checkpoint helicase
  • Target synonyms
    ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; excision repair cross-complementation group 6 like; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; excision repair protein ERCC6-like; PICH; Plk1-interacting checkpoint helicase; RAD26L; SNF2/RAD54 family protein; tumor antigen BJ-HCC-15
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203