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ProductsBack/ERG Antibody / Transcriptional regulator ERG

ERG Antibody / Transcriptional regulator ERG

ORB2637105
Biorbyt
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetERG
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Overview

  • Supplier
    Biorbyt
  • Product Name
    ERG Antibody / Transcriptional regulator ERG
  • Delivery Days Customer
    10
  • Application Supplier Note
    Optimal dilution of the recombinant ERG antibody should be determined by the researcher.
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml IHC-P
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    ERG/22R
  • Conjugate
    Unconjugated
  • Gene ID2078
  • Target name
    ERG
  • Target description
    ETS transcription factor ERG
  • Target synonyms
    ERG, ETS transcription factor; erg-3; erythroblast transformation-specific transcription factor ERG variant 10; ets-related; FUS/ERG fusion protein; p55; TMPRSS2/ERG fusion; transcriptional regulator ERG; transcriptional regulator ERG (transforming protein ERG); v-ets avian erythroblastosis virus E26 oncogene homolog; v-ets avian erythroblastosis virus E26 oncogene related; v-ets erythroblastosis virus E26 oncogene homolog; v-ets erythroblastosis virus E26 oncogene like
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP11308
  • Protein Name
    Transcriptional regulator ERG
  • Scientific Description
    ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells. ERG is expressed in virtually all endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal tumor, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumor, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodermal tumor, chondrosarcoma, osteosarcoma, and rhabdomyosarcoma. For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover, the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.
  • Reactivity
    Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203