ERI1 Antibody

Cusabio

ERI1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

ERI1

exoribonuclease 1

3' exoribonuclease; 3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; 3'HEXO; enhanced RNAi three prime mRNA exonuclease homolog 1; HEXO; histone mRNA 3' end-specific exonuclease; histone mRNA 3'-end-specific exoribonuclease; histone mRNA 3'-exonuclease 1; THEX1; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1

Rabbit

IgG

3'-5' exoribonuclease 1

RNA exonuclease that binds to the 3-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 and 3-hydroxyl groups at the last nucleotide of the histone 3-end is required for efficient degradation of RNA substrates. Also able to degrade the 3-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5-ACCCA-3 sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Dominski Z., Mol. Cell 12:295-305(2003). Ota T., Nat. Genet. 36:40-45(2004). Bechtel S., BMC Genomics 8:399-399(2007)

Human

-20°C or -80°C

12352203