ERK5-IN-2 [1888305-96-1]

MedChem Express

ERK5-IN-2 [1888305-96-1]

10

1888305-96-1

Research Use Only

98.97

C17H11BrFN3O2

388.19

ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 microM, 3 microM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis[1].

FC1=CC=CC(Br)=C1C(C2=CNC(C(NC3=CC=CN=C3)=O)=C2)=O

2°C to 8°C

12352200