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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA585877(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA585877(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA585877(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)

ERN2 Antibody

Research Use Only
CSB-PA585877
Cusabio
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetERN2
Price on request
Packing Size
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    Cusabio
  • Product Name
    ERN2 Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID10595
  • Target name
    ERN2
  • Target description
    endoplasmic reticulum to nucleus signaling 2
  • Target synonyms
    endoplasmic reticulum to nucleus signalling 2; ER to nucleus signalling 2; hIRE2p; inositol-requiring 1 beta; inositol-requiring protein 2; IRE1 beta; IRE1, S. cerevisiae, homolog of; IRE1b; IRE1-BETA; IRE2p; serine/threonine-protein kinase/endoribonuclease IRE2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ76MJ5
  • Protein Name
    Serine/threonine-protein kinase/endoribonuclease IRE2
  • Scientific Description
    The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1alpha and IRE1beta are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203