ERN2 Polyclonal Antibody

Reddot Biotech

ERN2 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

ERN2

endoplasmic reticulum to nucleus signaling 2

endoplasmic reticulum to nucleus signalling 2; ER to nucleus signalling 2; hIRE2p; inositol-requiring 1 beta; inositol-requiring protein 2; IRE1 beta; IRE1, S. cerevisiae, homolog of; IRE1b; IRE1-BETA; IRE2p; serine/threonine-protein kinase/endoribonuclease IRE2

Rabbit

IgG

The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1Oe+/- and IRE1beta are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

Human

-20°C

12352203