ERR alpha antibody [N1], N-term
GTX108166
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetESRRA
Overview
- SupplierGeneTex
- Product NameERR alpha antibody [N1], N-term
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.32 mg/ml
- ConjugateUnconjugated
- Gene ID2101
- Target nameESRRA
- Target descriptionestrogen related receptor alpha
- Target synonymsERR1, ERRa, ERRalpha, ESRL1, NR3B1, steroid hormone receptor ERR1, ERR-alpha, estrogen receptor-like 1, estrogen-related nuclear receptor alpha, nuclear receptor subfamily 3 group B member 1
- HostRabbit
- IsotypeIgG
- Protein IDP11474
- Protein NameSteroid hormone receptor ERR1
- Scientific DescriptionThe protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Nowińska K, Jabłońska K, Ciesielska U, et al. Association of Irisin/FNDC5 with ERRα and PGC-1α Expression in NSCLC. Int J Mol Sci. 2022,23(22). doi: 10.3390/ijms232214204Read this paper
- Cerutti C, Zhang L, Tribollet V, et al. Computational identification of new potential transcriptional partners of ERRα in breast cancer cells: specific partners for specific targets. Sci Rep. 2022,12(1):3826. doi: 10.1038/s41598-022-07744-wRead this paper
- Dong P, Ye G, Tu X, et al. Roles of ERRα and TGF-β signaling in stemness enhancement induced by 1 µM bisphenol A exposure via human neural stem cells. Exp Ther Med. 2022,23(2):164. doi: 10.3892/etm.2021.11087Read this paper
- Tsushida K, Tanabe K, Masuda K, et al. Estrogen-related receptor α is essential for maintaining mitochondrial integrity in cisplatin-induced acute kidney injury. Biochem Biophys Res Commun. 2018,498(4):918-924. doi: 10.1016/j.bbrc.2018.03.080Read this paper
- Carnesecchi J, Cerutti C, Vanacker JM, et al. ERRα protein is stabilized by LSD1 in a demethylation-independent manner. PLoS One. 2017,12(11):e0188871. doi: 10.1371/journal.pone.0188871Read this paper
- Luo C, Balsa E, Thomas A, et al. ERRα Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α-Elevated Melanomas. Mol Cancer Res. 2017,15(10):1366-1375. doi: 10.1158/1541-7786.MCR-17-0143Read this paper
- Carnesecchi J, Forcet C, Zhang L, et al. ERRα induces H3K9 demethylation by LSD1 to promote cell invasion. Proc Natl Acad Sci U S A. 2017,114(15):3909-3914. doi: 10.1073/pnas.1614664114Read this paper
- Tribollet V, Barenton B, Kroiss A, et al. miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα. PLoS One. 2016,11(5):e0156445. doi: 10.1371/journal.pone.0156445Read this paper
- Carnesecchi J, Malbouyres M, de Mets R, et al. Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. PLoS One. 2015,10(3):e0120672. doi: 10.1371/journal.pone.0120672Read this paper
- Sailland J, Tribollet V, Forcet C, et al. Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration. Proc Natl Acad Sci U S A. 2014,111(42):15108-13. doi: 10.1073/pnas.1402094111Read this paper
Datasheet
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