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ProductsBack/ERR alpha antibody [N1], N-term

ERR alpha antibody [N1], N-term

GTX108166
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetESRRA
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Overview

  • Supplier
    GeneTex
  • Product Name
    ERR alpha antibody [N1], N-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.32 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2101
  • Target name
    ESRRA
  • Target description
    estrogen related receptor alpha
  • Target synonyms
    ERR1; ERRa; ERRalpha; ERR-alpha; ESRL1; estrogen receptor-like 1; estrogen-related nuclear receptor alpha; NR3B1; nuclear receptor subfamily 3 group B member 1; steroid hormone receptor ERR1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP11474
  • Protein Name
    Steroid hormone receptor ERR1
  • Scientific Description
    The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Association of Irisin/FNDC5 with ERRalpha and PGC-1alpha Expression in NSCLC.
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  • Computational identification of new potential transcriptional partners of ERRalpha in breast cancer cells: specific partners for specific targets. Cerutti C et al., 2022 Mar 9, Sci Rep
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  • Roles of ERRalpha and TGF-beta signaling in stemness enhancement induced by 1 microM bisphenol A exposure via human neural stem cells. Dong P et al., 2022 Feb, Exp Ther Med
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  • Estrogen-related receptor alpha is essential for maintaining mitochondrial integrity in cisplatin-induced acute kidney injury. Tsushida K et al., 2018 Apr 15, Biochem Biophys Res Commun
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  • ERRalpha protein is stabilized by LSD1 in a demethylation-independent manner. Carnesecchi J et al., 2017, PLoS One
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  • ERRalpha Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1alpha-Elevated Melanomas. Luo C et al., 2017 Oct, Mol Cancer Res
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  • ERRalpha induces H3K9 demethylation by LSD1 to promote cell invasion. Carnesecchi J et al., 2017 Apr 11, Proc Natl Acad Sci U S A
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  • miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRalpha. Tribollet V et al., 2016, PLoS One
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  • Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. Carnesecchi J et al., 2015, PLoS One
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  • Estrogen-related receptor alpha decreases RHOA stability to induce orientated cell migration. Sailland J et al., 2014 Oct 21, Proc Natl Acad Sci U S A
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