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Figure: Specific quantitation of APRIL in human serum. Method: Serum from a healthy patient is left untreated or treated with 1microg/ml of the APRIL receptor, TACI (human):Fc (human) (Prod. No. AG-40B-0079). APRIL levels were measured us
Figure: Specific quantitation of APRIL in human serum. Method: Serum from a healthy patient is left untreated or treated with 1microg/ml of the APRIL receptor, TACI (human):Fc (human) (Prod. No. AG-40B-0079). APRIL levels were measured us
Figure: Specific quantitation of APRIL in human serum. Method: Serum from a healthy patient is left untreated or treated with 1microg/ml of the APRIL receptor, TACI (human):Fc (human) (Prod. No. AG-40B-0079). APRIL levels were measured us

Erythroferrone (human) ELISA Kit

Research Use Only
AG-45B-0014
AdipoGen Life Sciences
ReactivityHuman
Product group Assays
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Erythroferrone (human) ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.3125 to 20ng/ml
  • Assay Sensitivity
    270pg/ml
  • Assay Specificity
    Detects human Erythroferrone [Myonectin; CTRP15] in serum, plasma and cell culture supernatant.
  • Certification
    Research Use Only
  • Scientific Description
    ELISA Assay. Detects human Erythroferrone [Myonectin; CTRP15] in serum, plasma and cell culture supernatant. Colorimetric sandwich assay. Sample types: Cell Culture Supernatant, Plasma, Serum. Range: 0.3125 to 20ng/ml. Sensitivity: 270pg/ml. Erythroferrone (also called Myonectin, CTRP15 or Fam13B) is a member of CTRPs (C1q/TNF-related proteins), which are conserved paralogs of adiponectin containing collagen-like and globular C1q-like domains. Erythroferrone plays two different regulatory roles: i) Erythroferrone (called Myonectin for this role) is a myokine abundantly expressed in skeletal muscle tissue, upregulated by voluntary exercise that is suppressed by fasting and induced by refeeding; it participates in the regulation of systemic lipid metabolism by promoting the clearance of nonesterified fatty acids (NEFA) from circulation. As a myokine, Erythroferrone/Myonectin acts as an endurance exercise-driven myokine which protects the heart from ischemic injury by reducing cardiomyocyte apoptosis and macrophage inflammatory response, and ii) Erythroferrone is produced by erythroblasts after bleeding or EPO treatment and acts on hepatocytes to suppress hepcidin expression, resulting in increased release of iron from cellular iron stores. Erythroferrone acts on hepcidin by inhibiting members of the BMP-5, BMP-6 and BMP-7 subgroup of BMPs. Erythroferrone functions as erythroid modulator of iron metabolism and hemoglobin synthesis. Levels of Erythroferrone measured by this ELISA kit in serum and plasma correspond to mouse protein levels (~ 500ng/ml). Erythroferrone is a biomarker for different types of anemia, for cardiology and potentially also for metabolic diseases. - Erythroferrone (also called Myonectin, CTRP15 or Fam13B) is a member of CTRPs (C1q/TNF-related proteins), which are conserved paralogs of adiponectin containing collagen-like and globular C1q-like domains. Erythroferrone plays two different regulatory roles: i) Erythroferrone (called Myonectin for this role) is a myokine abundantly expressed in skeletal muscle tissue, upregulated by voluntary exercise that is suppressed by fasting and induced by refeeding; it participates in the regulation of systemic lipid metabolism by promoting the clearance of nonesterified fatty acids (NEFA) from circulation. As a myokine, Erythroferrone/Myonectin acts as an endurance exercise-driven myokine which protects the heart from ischemic injury by reducing cardiomyocyte apoptosis and macrophage inflammatory response, and ii) Erythroferrone is produced by erythroblasts after bleeding or EPO treatment and acts on hepatocytes to suppress hepcidin expression, resulting in increased release of iron from cellular iron stores. Erythroferrone acts on hepcidin by inhibiting members of the BMP-5, BMP-6 and BMP-7 subgroup of BMPs. Erythroferrone functions as erythroid modulator of iron metabolism and hemoglobin synthesis. Iron metabolism (including Hepcidin and Erythroferrone) is closely linked to viral infection (intrusion, replication) and might be an anitviral target (such as for SARS-CoV-2). Levels of Erythroferrone measured by this ELISA Kit in serum and plasma correspond to mouse protein levels (~500ng/ml). Our Erythroferrone assay has been validated by the Swiss Laboratory for Doping Analyses in a recent publication, reporting that our assay can sensitively detect the stimulation of erythropoiesis, including erythropoiesis stimulating agents (ESA, such as Erythropoietin) abuse and blood withdrawal. Erythroferrone is a biomarker for different types of anemia, for cardiology and potentially also for metabolic diseases.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158