Everafenib

TargetMol Chemicals

Everafenib

107

Chemical

Everafenib

C20H23ClFN5O2S2

484.01

Everafenib is a potent BRAF inhibitor that crosses the blood-brain barrier and also inhibits the MAPK pathway. Everafenib inhibits the activity of a range of V600EBRAF melanoma cell lines (IC50: 2-10 nM) and is more effective than Dabrafenib and Vemurafenib. Everafenib was effective in extending the number of days of survival in a mouse model of intracranial metastatic melanoma.

3 years

#Reference to error in column [smiles]

-20°

12352200