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Evo312

Research Use Only
HY-169006
MedChem Express
Molecular Weight361.39
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Evo312
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C21H19N3O3
  • Molecular Weight
    361.39
  • Scientific Description
    Evo312 is a dose-dependent inhibitor of protein kinase CbetaI (PKCbetaI) (IC50 is 117.34 nM). Evo312 induces PANC-GR (acquired gemcitabine-resistant PC cells) cell cycle arrest and apoptosis by inhibiting PKCbeta1 protein expression. Evo312 has antiproliferative effects in pancreatic cancer cells PANC-1 and PANC-GR cells with IC50 of 0.08 microM and 0.07 microM, and in human normal pancreatic ductal epithelial cells HPDE6-c7 with IC50 of 2.95 microM. Evo312 exhibits antitumor activity in a PANC-GR cell transplantation mouse model[1].
  • SMILES
    O=C1C2=C(N(C3N1CCC4=C3NC5=CC=C(OC(C)=O)C=C45)C)C=CC=C2
  • UNSPSC
    12352200