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ProductsBack/EX-527 [49843-98-3]

EX-527 [49843-98-3]

Research Use Only
E9201
LKT Laboratories
Estimated Purity≥99%
Product group Chemicals
€ 341,00
25 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    EX-527 [49843-98-3]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥99%
  • Format
    DMSO 49 mg/mL (197.01 mM); Ethanol 18 mg/mL (72.37 mM); Water Insoluble
  • Scientific Description
    SIRT1 inhibitor.; Selisistat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Akimova T, Xiao H, Liu Y, et al. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol. 2014 Feb 19. [Epub ahead of print]. PMID: 24549276. Gertz M, Fischer F, Nguyen GT, et al. Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. PMID: 23840057. Zhou X, Fan LX, Sweeney WE Jr, et al. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest. 2013 Jul 1;123(7):3084-98. PMID: 23778143. Beier UH, Wang L, Bhatti TR, et al. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol. 2011 Mar;31(5):1022-9. PMID: 21199917.