Exatecan intermediate 8

MedChem Express

Exatecan intermediate 8

14

Research Use Only

C30H34FN3O9S

631.67

Exatecan intermediate 8 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 microM)[1].

O=S(C)(O)=O.O=C1[C@@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(OC(C)(C)C)=O)C(C)=C(F)C=C6N=C4C3=C2)=O

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