(E/Z)-DMU2105

MedChem Express

(E/Z)-DMU2105 [1031063-36-1]

14

1031063-36-1

C18H13NO

259.30

(E/Z)-DMU2105 (Compound 7k) is a potent and highly selective CYP1B1 inhibitor. (E/Z)-DMU2105 inhibits human CYP1B1 enzyme bound to yeast-derived microsomes with an IC 50 value of 10 nM. (E/Z)-DMU2105 also potently inhibits CYP1B1 expressed within live recombinant yeast and human HEK293 kidney cells with an IC 50 value of 63.65 nM. (E/Z)-DMU2105 can be used for the research of cancer, glaucoma, ischemia and obesity [1] .

O=C(C1=CC=CN=C1)/C=C/C2=CC=C3C=CC=CC3=C2

12352200