F-14512

MedChem Express

F-14512

5

Research Use Only

97.48

C33H47N5O8

641.75

F-14512 is a targeted cytotoxic compound that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 combines an epipodophyllotoxin core that targets topoisomerase II with a spermine group that acts as a cell delivery vehicle, with improved selectivity for tumor cells. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and demonstrates high potency in multiple human cell lines (median IC 50 =0.18 microM). In the MX1 breast tumor xenograft model, F-14512 exhibits potent antitumor activity [1] .

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=CC(OCO5)=C5C=C4[C@@H](NC(CNCCCNCCCCNCCCN)=O)[C@@]2([H])CO1

2°C to 8°C

12352200