Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using Factor XIIIa Polyclonal Antibody at dilution 1:80
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using Factor XIIIa Polyclonal Antibody at dilution 1:80
F13A1 Polyclonal Antibody
E-AB-12903
Product group Antibodies
Overview
- SupplierElabscience
- Product NameF13A1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.1mg/ml
- Scientific DescriptionThis gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
- UNSPSC12352203