F5446
HY-150190
Overview
- SupplierMedChem Express
- Product NameF5446
- Delivery Days Customer5
- CertificationResearch Use Only
- Estimated Purity99.38
- Molecular FormulaC26H17ClN2O8S
- Molecular Weight552.94
- Scientific DescriptionF5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo [1] [2] [3] .
- SMILESO=C(C1=CC(C2=C(C3=O)NC=C2C(OCC4=CC=CC=C4)=O)=C(N1S(=O)(C5=CC=C(C=C5)Cl)=O)C3=O)OC
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200