F5446

TargetMol Chemicals

F5446

65

2304465-89-0

Chemical

F5446

C26H17ClN2O8S

552.94

F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 umol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.

3 years

S(=O)(=O)(N1C2=C(C3=C(C(=O)C2=O)NC=C3C(OCC4=CC=CC=C4)=O)C=C1C(OC)=O)C5=CC=C(Cl)C=C5

-20°

12352200